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Vetsulin® (porcine insulin zinc suspension) FAQs

These FAQs should answer most of your questions, but if there is something more you want to know you can always contact us or your veterinarian for more information.

Diabetes mellitus in dogs

Q. What is diabetes mellitus and what causes it? Q. I have heard about diabetes insipidus; is this the same as diabetes mellitus? Q. What signs do dogs with diabetes typically show? Q. What do the terms polyuria, polydipsia, and polyphagia mean? Q. My dog is having problems holding its urine; does that mean it has diabetes? Q. How is diabetes diagnosed? Q. Are all dogs susceptible to diabetes? Q. What other problems can be associated with diabetes? Q. What other diseases have the same signs as diabetes? Q. Did I do something to cause diabetes? Q. What is the difference between type 1 and type 2 diabetes? Q. What is the expected lifespan for a diabetic dog? Q. Is diabetes in animals similar to that of humans?

Vetsulin® (porcine insulin zinc suspension)

Q. Where on my dog's body should Vetsulin be injected? Q. Can I still use a vial of Vetsulin if it freezes? Q. Can I still use a vial of Vetsulin if it was forgotten outside the refrigerator between doses? Q. What else should I know about Vetsulin? Q. What should I do if I think that my dog has very low blood sugar (hypoglycemia)? Q. How much water should I let my dog drink? Q. What is the importance of making sure my pet is regulated? Q. How long does it take to regulate a diabetic animal? Q. My dog is ill and not eating. Should I still give him/her an insulin injection? Q. Should I feed my dog before or after an injection? Q. What can I give my dog as a treat? Q. What does the typical diet consist of? Q. What is a blood glucose curve? Q. What are some problems with blood glucose curves? Q. How often should a blood glucose curve be done? Q. What is stress hyperglycemia? Q. What is fructosamine?

VetPen®

Q. What makes VetPen unique? Q. Is VetPen difficult to use? Q. How do I measure insulin doses with VetPen? Q. Can I take VetPen with me when I travel? Q. Is VetPen reusable? Q. Can VetPen be used with different insulins? Q. Does VetPen offer any other benefits over traditional insulin vials and syringes? Q. What type of needle is used with VetPen? Q. Can VetPen needles be reused? Q. What if less than a whole dose is administered? Q. How do I take care of VetPen?

General questions

Q. How often should my diabetic dog see the veterinarian? Q. Should my diabetic dog still receive vaccinations? Q. Is it safe for a dog with diabetes mellitus to receive a general anesthetic?

Diabetes mellitus in dogs

Q. What is diabetes mellitus and what causes it?
A.
Diabetes mellitus is caused by an absolute or relative deficiency of insulin. Animals with an absolute or relative deficiency of insulin are called diabetics.

Insulin deficiency can develop for different reasons:

  • Disorders of the pancreas—the pancreas is unable to secrete enough insulin.
  • Other diseases or the presence of other hormones—may be antagonistic to insulin or cause resistance to insulin. Insulin is unable to function normally in the body.

Q. I have heard about diabetes insipidus; is this the same as diabetes mellitus?
A.
No. Diabetes insipidus, also known as water diabetes, is caused when large amounts of dilute urine are produced. It is a far less common condition than diabetes mellitus. Diabetes insipidus is caused by problems in part of the brain or in the kidneys. There is no glucose present in the urine of animals with diabetes insipidus.

Q. What signs do dogs with diabetes typically show?
A.
The most common signs of diabetes mellitus in dogs are:

  • Increased drinking
  • Increased urination
  • Increased appetite
  • General signs, such as lethargy and poor coat condition

Q. What do the terms polyuria, polydipsia, and polyphagia mean?
A.
Polyuria is the production of large amounts of urine in a given period (eg, per day). Polydipsia is chronic excessive thirst. Polyphagia is great hunger.

Q. My dog is having problems holding its urine; does that mean it has diabetes?
A.
No, your dog could have a bladder or kidney infection, or some other medical problem. If your dog is having problems holding its urine, you should schedule a trip to your veterinarian as soon as possible.

Q. How is diabetes diagnosed?
A.
Your veterinarian will measure your dog's blood glucose and test your dog's urine for the presence of glucose and ketones. Persistently high blood glucose levels along with glucose in the urine usually means that your dog has diabetes mellitus.

Q. Are all dogs susceptible to diabetes?
A.
Dogs of all ages can get diabetes. Diabetes most typically occurs in older dogs. Obesity, genetics, and other conditions can contribute to the development of diabetes.

Q. What other problems can be associated with diabetes?
A.
Problems associated with diabetes are generally seen in long-standing cases; they include cataracts in dogs and chronic infections.

Q. What other diseases have the same signs as diabetes?
A.
Dogs with diabetes mellitus drink and urinate a lot. They may also have a good or increased appetite but usually lose rather than gain weight. Other common diseases where some or all of these signs are also seen include:

  • Cushing's disease (hyperadrenocorticism)
  • Exocrine pancreatic insufficiency
  • Kidney disease

To reach a definitive diagnosis of diabetes mellitus, your veterinarian will test your dog's blood glucose levels and for the presence of urine glucose and ketones.

Q. Did I do something to cause diabetes?
A.
No. Diabetes mellitus is due to a lack of insulin produced by the pancreas. It is not caused by a virus or infection. Diabetes in dogs is thought to be an autoimmune disease.

Q. What is the difference between type 1 and type 2 diabetes?
A.
Insulin is produced by the beta cells in the pancreas. Type 1 diabetes is due to the destruction of the beta cells with progressive and eventual complete loss of insulin secretion. This type always requires insulin therapy. Type 2 diabetes is characterized by dysfunctional beta cells (irregular insulin production) or the other cells of the body not responding to insulin properly. Type 2 diabetes may or may not require insulin therapy. In general, all diabetic dogs have type 1 diabetes and require insulin to control their disease. Unlike dogs, cats can fall under the type 1 or type 2 classifications.

Q. What is the expected lifespan for a diabetic dog?
A.
It is only recently that dogs were treated aggressively for diabetes. Sadly, not many years ago these animals would have automatically been euthanized. Today, studies suggest that, if a dog is kept well regulated and does not have any other health problems, he or she should be able to have a normal life expectancy.

Is diabetes in animals similar to that of humans?
A.
Yes, it is very similar. Your dog will be using similar medications, equipment, and monitoring methods as human diabetics use.

Vetsulin® (porcine insulin zinc suspension)

Q. Where on my dog's body should Vetsulin be injected?
A.
Injections should be given subcutaneously (under the skin) about 1 to 2 inches below the spine or backbone. Constantly vary the injection location from behind the shoulder blade to just in front of the hip bone, and alternate injections between your pet's left and right sides. Your veterinarian can help guide you as to the recommended locations for injections. Download the Administration Sheet for instructions on how to administer Vetsulin to your dog.

Q. Can I still use a vial of Vetsulin if it freezes?
A.
No, freezing will damage the insulin molecules and reduce the efficacy of the product. If a vial of insulin accidentally freezes in the refrigerator, it should be discarded and a new vial should be used.

Q. Can I still use a vial of Vetsulin if it was forgotten outside the refrigerator between doses?
A.
Ideally, Vetsulin should be stored upright, protected from light, between 2°C and 8°C (35°F and 46°F). Vetsulin should always remain refrigerated. If you accidentally leave a vial out of the refrigerator, contact your veterinarian for instructions.

Q. What else should I know about Vetsulin?
A.

  • Always have a spare vial on hand
  • Protect it from light
  • Keep it refrigerated
  • If it has gotten too hot, or frozen, discard it immediately
  • Discard contents after 42 days of the first vial puncture

If you see any of these signs, try to encourage your dog to eat a small meal or, if this fails, rub some corn syrup on your dog's gums.

Q. What should I do if I think that my dog has very low blood sugar (hypoglycemia)?
A.
The following signs may indicate hypoglycemia:

  • Restlessness
  • Trembling or shivering
  • Unusual movements or behavior
  • Unusual quietness or sleepiness
  • Loss of consciousness (coma)

If your dog is conscious, you should immediately treat your dog by pouring a small amount of a sugar solution (eg, corn syrup) onto your finger and then rubbing it onto your dog's gums. The sugar is absorbed very quickly and your dog should respond in 1 to 2 minutes. The sugar solution should never be poured directly into your dog's mouth since there is a risk that the solution will be inhaled into the lungs. Once your dog has responded to the sugar administration and is sitting up, it can be fed a small meal. Once the dog has stabilized, it should be transported to your veterinarian for evaluation.

How much water should I let my dog drink?
A.
If your dog is diabetic, and drinking excessive amounts of water, give him/her all it can drink. Your dog's body is trying to combat the high blood glucose level by expelling the excess sugar out of its body through the urine. Once your dog is regulated, this will subside.

Q. What is the importance of making sure my pet is regulated?
A.
If diabetes is left untreated or unregulated, it could cause many complications. These include cataracts, blindness, infections, and in extreme cases, death.

Q. How long does it take to regulate a diabetic animal?
A.
Each case is different. There is no way to put a specific time on it. Sometimes the regulation process will require you to try different dosages, diets, or injection frequencies. Regulation can be achieved sometimes within a month, and in some cases, over a year from the time therapy first started. It is very important to work closely with your veterinarian during this process to avoid further complications. Even after your dog is regulated, frequent veterinarian visits will be necessary to maintain good health.

Q. My dog is ill and not eating. Should I still give him/her an insulin injection?
A. If your dog is not eating—do not give Vetsulin or any other insulin!
If your dog has a reduced appetite, consult your veterinarian on how to proceed with insulin injections.

Q. Should I feed my dog before or after an injection?
A.
It is very important that your dog eats before you administer the injection of Vetsulin. The safest method is to feed your dog first, then give the injection.

Q. What can I give my dog as a treat?
A.
Your veterinarian will be the best person to determine your dog's diet, as he/she best knows its needs. Ask about treats. He/she can probably help you find an appropriate treat for your dog.

Q. What does the typical diet consist of?
A.
To keep constant from day to day, it is best to use commercially produced rather than homemade foods. Certain high-fiber prescription veterinary diets can be a useful adjunct to Vetsulin therapy. These diets should be avoided in underweight diabetic dogs. If special diets are unavailable, or your dog does not eat the diets, then standard canned dog foods are acceptable.

Q. What is a blood glucose curve?
A.
This is where the blood glucose is measured every 2 hours through the day. The dog should be on the same food schedule as at home. For most dogs, a 10-12 hour curve is adequate but in some instances a longer curve may be needed. Insulin effectiveness, glucose nadir (the lowest glucose reading), and duration of insulin effect are the critical parameters one learns from a glucose curve. The dosage of insulin, frequency of insulin administration, and feeding times may be altered based on these results.

Q. What are some problems with blood glucose curves?
A.
The results of the curve can be affected by several factors that may make the curve done at the veterinarian's office an inaccurate portrayal of what is occurring at home. Things such as inappetence (not eating) and stress (causing hyperglycemia) may occur at the veterinarian's office. Because some dogs refuse to eat at the veterinarian's office, the dog is fed at home first and samples are done until the next scheduled meal. This will give a more representative curve than a dog that has not eaten. In addition, it is not uncommon for curves to vary from day to day because many things can affect blood glucose levels such as appetite, digestion, metabolism, exercise, hormones, stress, etc.

Q. How often should a blood glucose curve be done?
A.
Once regulated, probably minimally every 6 months, or more frequently if a problem is suspected. Your veterinarian will advise you on the frequency.

Q. What is stress hyperglycemia?
A.
Stress hyperglycemia is caused when the animal is frightened or stressed. It is caused by the release of epinephrine (adrenaline). Glycosuria (glucose in the urine) is usually absent with stress hyperglycemia, because the blood glucose does not stay high for a significant period and therefore does not spill into the urine. Stress hyperglycemia does not influence the diagnosis of diabetes because the blood glucose level does not stay elevated long enough to cause glucose to spill into the urine.

Q. What is fructosamine?
A.
Fructosamine is a type of protein in the blood that can be used to measure glycemic (glucose) control over a longer period. Unlike blood glucose measurements, fructosamine is not affected by stress or the timing of the insulin injection. Your veterinarian may recommend periodic measurements of fructosamine to evaluate how well your pet's blood glucose level has been controlled over the last few weeks.

VetPen®

Q. What makes VetPen unique?
A.
While insulin pens have been commonly used in the management of human diabetes for some time, VetPen is the first such device designed exclusively for use in diabetic cats and dogs. Previously, the only approved way to give Caninsulin injections was to use vials and syringes, which some pet owners found inconvenient and overwhelming. While human insulin pens are used to administer insulin with a concentration of 100 IU per mL, VetPen works specifically with 40 IU per mL Caninsulin, which is tailor-made for use in pets.

Q. Is VetPen difficult to use?
A.
VetPen is ergonomically designed to make handling easy and the dosing process simple. It also reduces the time it takes to prepare and give insulin injections. It's easy enough to use even for pet owners with poor eyesight, arthritis, or any other condition that may cause unsteady hands.

Q. How do I measure insulin doses with VetPen?
A.
The user-friendly instrumentation of VetPen enables you to provide a precise dose of Caninsulin to your pet at each injection. VetPen eliminates the need to draw up doses from a vial using an insulin syringe. After preparing the device, you simply turn the dial and it draws up the selected dose for you. You then insert the needle through the skin and inject the insulin into your pet with the push of a button. This simple process enables greater accuracy and reduces the chance of user error.

Q. Can I take VetPen with me when I travel?
A.
The all-in-one construction of VetPen allows you to take it with you while away from home and makes it easy for you to give your pet its insulin nearly anywhere. The VetPen Starter Kit includes a handy travel pouch that holds the VetPen, needles, needle remover, and insulin, as well as the Dose Selector Adaptor and Release Button extensions.

Q. Is VetPen reusable?
A.
VetPen contains a reusable insulin cartridge that allows you to provide Caninsulin doses with minimal preparation time. It is still necessary to prime VetPen before using a new cartridge and to mix Caninsulin prior to each injection to remove any air bubbles. When the cartridge is empty, you simply remove it and insert a new one. The warranty for VetPen covers at least 3,000 uses.

Q. Can VetPen be used with different insulins?
A.
VetPen has been designed specifically for use with Caninsulin, the world's most trusted veterinary insulin, proven safe and effective for almost 20 years in millions of diabetic pets. To avoid dosing errors, other types of insulin cartridges for other types of insulin should not be used with VetPen.

Q. Does VetPen offer any other benefits over traditional insulin vials and syringes?
A.
VetPen helps enhance use by:

  • Lowering the risk of accidental needle stick injuries
  • Protecting the insulin cartridge from breakage thanks to its sturdy design
  • Reducing the likelihood of insulin spills
  • Reducing air bubbles that lead to inaccurate dosing

Q. What type of needle is used with VetPen?
A.
VetPen uses 29 gauge, 12mm pen needles only, which are small, thin, and specially lubricated. These are the only needles that should be used with VetPen. Always use a new needle for each injection.

Q. Can VetPen needles be reused?
A.
A new needle should be used with each injection. The needle should be removed with the needle remover and safely disposed of immediately after use. Reusing a needle may lead to insulin contamination, needle blockage, and/or inaccurate dosing.

Q. What if less than a whole dose is administered?
A.
If the dose selector of VetPen stops before the start line returns to the arrow, this indicates that your pet has not received the full insulin dose. If only a partial dose is administered or your pet dislodges the needle before the count of 5, do not attempt to inject again. Wait for your pet's next scheduled injection.

Q. How do I take care of VetPen?
A.
VetPen should always be stored or carried with the needle removed and the cap on. To clean VetPen, simply wipe with a damp cloth. Do not immerse it in water. Keep Caninsulin cartridges refrigerated and protected from light prior to use. Do not freeze.

General questions

Q. How often should my diabetic dog see the veterinarian?
A.
If healthy and well regulated, most experts recommend every 3 months. Talk to your veterinarian about how often they would like to see your dog.

Q. Should my diabetic dog still receive vaccinations?
A.
It is perfectly safe for your diabetic dog to receive its vaccinations. In fact, this annual visit also gives your veterinarian a good opportunity to give your pet a complete checkup. By keeping your diabetic dog healthy, there will be fewer fluctuations in its insulin requirements.

Q. Is it safe for a dog with diabetes mellitus to receive a general anesthetic?
A.
Normally animals need to have an empty stomach before they are anesthetized. A diabetic dog that has not been fed needs far less insulin. Your veterinarian will advise you on how much insulin to give your dog before it is admitted or may wish to administer a reduced dose of insulin for you. Usually a diabetic dog is administered intravenous fluid therapy while under anesthesiA. This hydrates the animal when it cannot drink on its own. Apart from needing a reduced amount of insulin and fluid therapy (which is also given to some non–diabetic animals undergoing anesthesia), your diabetic dog is not at any additional risk from anesthesia than a non–diabetic dog of the same age.

Important Safety Information
Vetsulin should not be used in dogs or cats known to have a systemic allergy to pork or pork products. Vetsulin is contraindicated during periods of hypoglycemiA. Keep out of reach of children. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and prevent associated complications. Overdosage can result in profound hypoglycemia and death. The safety and effectiveness of Vetsulin in puppies and kittens, breeding, pregnant, and lactating dogs and cats has not been evaluated. See package insert for full information regarding contraindications, warnings, and precautions.